Bone regeneration biomarkers in maxillofacial surgery: a critical review of literature

Relevance . Drug-associated osteonecrosis is known to cause some pathological changes. The titers of biomarkers responsible for bone metabolism are also subject such They essential in the diagnosis and treatment planning, especially during surgical interventions, because risk osteonecrosis. Purpose – based on data modern scientific literature articles, identifying markers remodeling endothelial disorders primary importance optimizing early microcirculati patients with maxillofacial pathologies. Materials methods A review available normal anatomy, biomarkers, regulatory factors. study diagnostic modes identification most valuable fastest vascular endothelium impairment. Results According studies, osteocalcin, C-terminal telopeptide, tartrate-resistant acid phosphatase VEGF clinically informative predicting jawbone With a serum telopeptide concentration less than 100 pg/mL, increases. Serum osteocalcin specific biomarker osteoblast function assessing rate formation osteoporosis. average level revealed significant difference between postmenopausal osteoporotic (16.16 ± 4.5 ng/ml) non-osteoporotic (11.26 3.07 women. Tartrate-resistant (TRAP 5b) used reference activity number osteoclasts. TRAP 5b can be specifically detected by immunoassays. Conclusion degeneration allows us understand principles occurrence more clearly, and, therefore, clearly predict, diagnose osteonecrosis, correctly select tactics these patients, type intervention, conservative, operative (partial resection, total jaw resection), palliative, pre- post-drug preparation body intervention.